CD161+ regulatory t cells in immune regulation
نویسندگان
چکیده
Introduction Regulatory T cells (Treg) are crucial for maintaining immune homeostasis and mediating immune tolerance. Several studies have shown that Treg can produce cytokines. CD161, a C-type lectin receptor, identifies Treg that produce cytokines. Interestingly, CD161+ Treg are enriched in the inflamed joint of Juvenile Idiopathic Arthritis (JIA) patients and their numbers relate to clinical disease severity suggesting that CD161+ Treg may play an important role in disease pathogenesis. If Treg are to be used as a cell therapy it may be important to define ways to prevent cytokine production from these cells in vivo.
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